Polymerase Proofreader

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by Yongqin Gao The Open Source Software (OSS) development movement is a classic example of a social network. It is also a prototype of a complex evolving network. After two years of collecting developer and project information from SourceForge, we have sufficient data to determine the dynamic and structural mechanisms that govern the evolution and topology of this complex system. First, we anal...

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by Xiaorong Xiang Natural organic matter (NOM), a heterogeneous mixture of molecules, plays a crucial role in the evolution of soils, the transport of pollutants, and the change of global weather. The evolution of NOM over time is an important research area in biology, geochemistry, ecology, soil science, and water resource. Due to its complexity and the structural heterogeneity, new simulation...

A direct proofreader-clamp interaction stabilizes the Pol III replicase in the polymerization mode.

Processive DNA synthesis by the αεθ core of the Escherichia coli Pol III replicase requires it to be bound to the β2 clamp via a site in the α polymerase subunit. How the ε proofreading exonuclease subunit influences DNA synthesis by α was not previously understood. In this work, bulk assays of DNA replication were used to uncover a non-proofreading activity of ε. Combination of mutagenesis wit...

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by Guangyue Han Recently there has been considerable interest in wireless communication systems using multiple antennas. Theoretical analysis shows that such systems can provide spacial and temporal diversity gain if appropriate signal sets are employed. This dissertation analyzes and designs suitable signal constellations for such systems. Diversity product and diversity sum will be derived as...

This Page Is Not Part of the Thesis, but Should Be Turned in to the Proofreader!